Diabetic Retinopathy and NADPH Oxidase-2: A Sweet Slippery Road
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چکیده
منابع مشابه
NADPH Oxidase-2 and Atherothrombosis
Atherothrombosis encompasses a sequence of events whose hallmarks are atherosclerotic plaque formation and the ensuing thrombotic complications at sites of plaque rupture or erosion. Key steps in the atherosclerosis process include accumulation and oxidation of low-density lipoproteins (LDLs) by reactive oxygen species (ROS) within the artery wall and perpetuation of the inflammatory process vi...
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Objectives. Using apocynin (inhibitor of NADPH oxidase), and Mitoquinol 10 nitrate (MitoQ; mitochondrial-targeted antioxidant), we addressed the importance of mitochondria versus NADPH oxidase-derived ROS in glucose-induced apoptosis of pericytes. Methods. NADPH oxidase was localised using Western blot analysis and cytochrome C reduction assay. Apoptosis was detected by measuring caspase-3 acti...
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AIMS Ischemic retinal diseases such as retinopathy of prematurity are major causes of blindness due to damage to the retinal microvasculature. Despite this clinical situation, retinopathy of prematurity is mechanistically poorly understood. Therefore, effective preventative therapies are not available. However, hypoxic-induced increases in reactive oxygen species (ROS) have been suggested to be...
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Oxidative stress plays an important role in the development of renal damage in diabetes and hypertension. The major source of oxidative stress is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived superoxide anion (O2 ) that directly damage cell and also activate signaling of cell proliferation, adhesion molecules, and fibrosis. O2 .also inactivates endothelium derived nitric o...
متن کاملA Multifarious NADPH Oxidase
Nox4, one of the 7 isoforms of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase family that generate reactive oxygen species, was first identified in the early 2000s in kidneys.1 Nox4 was originally described as an oxygen sensor and regulator of kidney cell growth and because of its renal abundance was termed “renox.”1 It soon became evident that Nox4 has a ubiquitous distributio...
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2021
ISSN: 2076-3921
DOI: 10.3390/antiox10050783